• Clinical characteristics, mortality and pain tolerance in stable versus acute presentation of coronary heart disease 

      Fladseth, Kristina (Doctoral thesis; Doktorgradsavhandling, 2022-09-30)
      <p>Despite immense progress in the prevention, diagnosis and treatment of coronary heart disease, several challenges remain. In more than half of patients referred to coronary angiography for stable and unstable angina, no obstructive coronary artery disease (CAD) is found. At the same time, some patients present for the first time with already extensive CAD. Further, the management of unstable ...
    • Kan troponiner brukes til å selektere elektive pasienter med nytte av koronar angiografi? 

      Fladseth, Kristina (Master thesis; Mastergradsoppgave, 2016-06-01)
      Innledning: På Universitetssykehuset i Nord-Norge (UNN) har andelen obstruktiv koronarsykdom på elektiv invasiv koronar angiografi (IKA) falt fra 76 % i 2012 til 54 % i 2005. Det er behov for å gjøre en bedre forhåndsseleksjon av pasienter for å spare samfunnets ressurser og pasienten fra unødvendige engstelse og komplikasjonsfare. Høysensitiv troponin (hs-cTn) brukes for å diagnostisere akutt ...
    • Low pain tolerance is associated with coronary angiography, coronary artery disease, and mortality: The TROMSO study 

      Fladseth, Kristina; Lindekleiv, Haakon; Nielsen, Christopher Sivert; Øhrn, Andrea; Kristensen, Andreas; Mannsverk, Jan Torbjørn; Løchen, Maja-Lisa; Njølstad, Inger; Wilsgaard, Tom; Mathiesen, Ellisiv B.; Stubhaug, Audun; Trovik, Thor; Rotevatn, Svein; Forsdahl, Signe Helene; Schirmer, Henrik (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-11-03)
      BACKGROUND: The initial presentation to coronary angiography and extent of coronary artery disease (CAD) vary greatly among patients, from ischemia with no obstructive CAD to myocardial infarction with 3-vessel disease. Pain tolerance has been suggested as a potential mechanism for the variation in presentation of CAD. We aimed to investigate the association between pain tolerance, coronary ...
    • Outcomes after coronary angiography for unstable angina compared to stable angina, myocardial infarction and an asymptomatic general population 

      Fladseth, Kristina; Wilsgaard, Tom; Lindekleiv, Haakon; Kristensen, Andreas; Mannsverk, Jan Torbjørn; Løchen, Maja-Lisa; Njølstad, Inger; Mathiesen, Ellisiv B.; Trovik, Thor; Rotevatn, Svein; Forsdahl, Signe Helene; Schirmer, Henrik (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-07-31)
      Background: The outcomes of real-world unstable angina (UA) in the high-sensitivity troponin era are unclear. We aimed to investigate the outcomes of UA referred to coronary angiography compared to stable angina (SA), nonST-segment elevation myocardial infarction (NSTEMI), STEMI and a general population.<p> <p>Methods: We included the 9,694 patients with no prior coronary artery disease (CAD) ...
    • Pre-test characteristics of unstable angina patients with obstructive coronary artery disease confirmed by coronary angiography 

      Fladseth, Kristina; Kristensen, Andreas; Mannsverk, Jan T.; Trovik, Thor; Schirmer, Henrik (Master thesis; Mastergradsoppgave, 2017-10-31)
      Objective As the mortality and rate of obstructive coronary artery disease (CAD) is low in patients with unstable angina (UA), better pre-test selection criteria for acute coronary angiography (CAG) is warranted. We aimed to validate the current guidelines against other clinical variables as predictors of obstructive CAD in UA patients referred for acute CAG. Methods From 2005 to 2012, all CAGs ...
    • Pre-test characteristics of unstable angina patients with obstructive coronary artery disease confirmed by coronary angiography 

      Fladseth, Kristina; Kristensen, Andreas; Mannsverk, Jan; Trovik, Thor; Schirmer, Henrik (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-11-01)
      <p><i>Objective</i>: Patients referred for acute coronary angiography (CAG) with unstable angina (UA) have low mortality and low rate of obstructive coronary artery disease (CAD). Better pre-test selection criteria are warranted. We aimed to assess the current guidelines against other clinical variables as predictors of obstructive CAD in patients with UA referred for acute CAG.</p> <p><i>Methods</i>: ...